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KMID : 0378019820250120095
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New Medical Journal
1982 Volume.25 No. 12 p.95 ~ p.102
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Effects of Long-term Dapsone Treatment on Haemoglobin and Serum Ferritin Levels in Leprosy Patients
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姜榮振/Kang, Y.J.
孫東烈/金仁樹/徐大圭/Sohn, D.R./Kim, I.S./Suh, T.K.
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Abstract
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It is well known fact that patients with leprosy are likely to have anaemia. Furthermore, the chief therapeutic agent for this disease, Dapsone, itself causes anaemia.
To determine the reason for anaemia in leprosy and effect of longterm Dapsone on the anaemia, the levels of haemoglobin and serum ferritin in the sera collected from each of twenty-five lepromatous and tuberculoid patients belonging to the Leprosy Hospital, AERACK WON, Daegu, Korea were analyzed. The sera from twenty-five healthy adults were included in the study as controls. The haemoglobin levels of lepromatous patients averaged 11.6 (SD ±0.8) gm per 100m1, while the haemoglobin level of tuberculoid group averaged 11.5 (SD± 0.8) gm per 100ml compared with a normal of 14.6 (SD±0.9) gm per 100ml. There was significant difference, p.<0.001, in the average values of haemoglobin between leprosy patients of both type and contol but not between lepromatous and tuberculoid.
Average values, ng per ml, of serum ferritin in lepromatous patients were 99.4±42.7 while in tuberculoid patients were 89.1±46.7 compared with control of 92.1±35.2. No significant difference was observed in leprosy patients and contol.
The dosage regime of Dapsone for patients who were administred during this study was 300mg per week. When the average haemoglobin and serum ferritin levels were analyzed with the duration of, 6 to 38 years, Dapsone therapy in the both type of patients, no significant difference was observed.
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